Coupling of Petri Net Models of the Mycobacterial Infection Process and Innate Immune Response

TitleCoupling of Petri Net Models of the Mycobacterial Infection Process and Innate Immune Response
Publication TypeJournal Article
Year of Publication2015
AuthorsCarvalho, R., van den Heuvel J., Kleijn J., Verbeek F.
JournalComputation
Volume3
Pagination150 - 176
Date Published6/2015
Abstract

Computational and mathematical modeling is important in support of a better understanding of complex behavior in biology. For the investigation of biological systems, researchers have used computers to construct, verify, and validate models that describe the mechanisms behind biological processes in multi-scale representations. In this paper we combine Petri net models that represent the mycobacterial infection process and innate immune response at various levels of organization, from molecular interaction to granuloma dissemination. In addition to the conventional graphical representation of the Petri net, the outcome of the model is projected onto a 3D model representing the zebrafish embryo. In this manner we provide a visualization of the process in a simulation framework that portrays the infection in the living system.

DOI10.3390/computation3020150
Short TitleComputation
DOI10.3390/computation3020150
15/03/2016