Bio-imaging technology for better diagnostic tools
WP2.3 Imaging mass spectrometry
Many diseases are associated with variations in the amount of certain proteins as well as their distribution in cells and tissue. While conventional mass spectrometry (MS) measures the molecular content, Imaging MS can also be used for analysing the distribution. We will develop and implement a new high throughput imaging mass spectrometer and integrate it with existing mass spectrometry. With this technology we will analyse samples of patients with cardiovascular diseases, cancer and neurodegenerative disorders.
Figure: Imaging mass spectrometry shows the distribution of biomarkers with different colours in tissue (top) and the mass spectra of different regions (bottom).